• Trial Status
  • Patients randomised:
  • 7112

Brief Summary

A 5-year multicentre clinical trial to investigate the efficacy of removing nitrous oxide (N2O) from the anaesthetic gas mixture in patients with coronary artery disease undergoing major surgery.

  1. Group 1 – General anaesthesia and FiO2 0.30 with N2O
  2. Group 2 – General anaesthesia and FiO2 0.30 without N2O

The trial commenced enrolment in May 2007.

Main Study Hypothesis

1. In patients undergoing anaesthesia for major surgery, avoidance of N2O will reduce the incidence of cardiac complications, stroke or death when compared with otherwise identically managed surgical patients receiving N2O as a component of their anaesthesia.

2. The incidence, clinical importance, risk factors, and economic costs of cardiac events and mortality in patients undergoing anaesthesia for major surgery can be determined in a large cohort of surgical patients with known or suspected coronary artery disease.


Australian NHMRC Project Grant


clinicaltrials.gov ID CT00430989

For further information contact

Sophie Wallace